![]() The container-emulsion unit is a closed system and is not dependent upon entry of external air during administration. The container is nontoxic and biologically inert. This product is not made with natural rubber latex. The container does not contain DEHP (di(2-ethylhexyl) phthalate) or PVC. It contains no plasticizers and exhibits virtually no leachables. The film is polypropylene based comprising three co-extruded layers. The primary plastic container (Biofine TM) is made from multilayered film specifically designed for parenteral nutrition drug products. The phospholipids present contribute 47 milligrams or approximately 1.5 mmol of phosphorus per 100 mL of the emulsion. The total caloric value, including fat, phospholipid and glycerin, is 3.0 kcal per mL of Intralipid 30%. Fat Emulsion) has an osmolality of approximately 310 mOsmol/kg water (which represents 200 mOsmol/L of emulsion) and contains emulsified fat particles of approximately 0.5 micron size. Glycerin is chemically designated C 3H 8O 3 and is a clear colorless, hygroscopic syrupy liquid. R 3 is primarily either the choline or ethanolamine ester of phosphoric acid. These phospholipids have the following general structure:Ĭontain saturated and unsaturated fatty acids that abound in neutral fats. Purified egg phosphatides are a mixture of naturally occurring phospholipids which are isolated from the egg yolk. These fatty acids have the following chemical and structural formulas: ![]() The major component fatty acids are linoleic acid (44-62%), oleic acid (19-30%), palmitic acid (7-14%), α-linolenic acid (4-11%) and stearic acid (1.4-5.5%) 1. Intravenous lipid therapy calcium channel blocker overdose emergency, poisoning β-blocker overdose.Where are saturated and unsaturated fatty acid residues. We suggest ILE administration for the treatment of cardiogenic shock due to CCB and BB overdose. Clinically significant adverse effects were uncommon. There was 93.3% survival in patients receiving ILE for drug-induced cardiovascular collapse. Two patients developed hypoxic ischemic encephalopathy, one patient died, and 14 patients (93.3%) were discharged from hospital. Two patients underwent mechanical ventilation. Adverse effects of ILE therapy were seen in three patients (20%). Three patients (20%) had resistant hypotension, one of whom progressed to pulmonary edema. ILE therapy was effective in 12 patients (80%). Drug exposures included CCBs (n = 8, 53.3%), CCBs and paracetamol (n = 1, 6.6%), and BBs (n = 6, 40%). ![]() Hospitalization durations variated between 3 and 33 days (mean 7.46 ± 7.41 days). We identified 15 patients who received ILE therapy for CCB and BB toxicity. This is a retrospective study in which we have summarized data of patients who were admitted to a university-based emergency department in a period of 3 years and were given intravenous lipid emulsion (ILE) to manage cardiogenic shock due to CCB and BB overdose. The objective of this study was to assess the efficacy of lipid emulsion as antidotal therapy in severe calcium channel blocker (CCB) and β-blocker (BB) intoxications.
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